1. Marcus Stroud, DT (2001 - 13th Overall)
Marcus Stroud was one of Tom Coughlin's finest draft picks. The Pro Bowl defensive tackle played for the Jaguars until 2008, when he was traded to the Buffalo Bills. Stroud eventually came back and signed a one-day contract to retire a Jaguar in 2012.
2. John Henderson, DT (2002 - 9th Overall)
John Henderson joined Marcus Stroud to form a defensive-tackle tandem that would go on to stuff running backs and harass quarterbacks for years. But like Stroud, Henderson aged and was eventually traded (Oakland Raiders - 2009). He was a two-time Pro-Bowler for the Jaguars and a fan favorite.
3. Byron Leftwich, QB (2003 - 7th Overall)
Byron Leftwich was drafted to be Jacksonville's next franchise quarterback -- Mark Brunell's replacement. While he did replace Brunell in his rookie season, he never delivered a season comparable to the left-handed signal caller. Leftwich was cut prior to the 2007 season. He's gone on to have a solid career as the Pittsburgh Steelers' backup.
4. Reggie Williams, WR (2004 - 9th Overall)
Reggie Williams was the second receiver drafted by the Jaguars in club history. Like the first (R. Jay Soward), Williams had a disappointing rookie season and was a bust. He never broke 700 receiving yards and was out of the NFL by 2009.
5. Matt Jones, WR (2005 - 21st Overall)
Like the two wide receivers drafted by the Jaguars in previous years, Matt Jones is generally considered a bust. The converted college quarterback never displayed the playmaking ability he was drafted for, and was eventually cut by the Jaguars after a few off-the-field incidents.
6. Marcedes Lewis, TE (2006 - 28th Overall)
Marcedes Lewis took a few years to develop, but eventually turned into one of the NFL's best blocking tight ends and a solid receiver in the middle of the field. In 2010, Lewis tied a Jaguars record with 10 touchdown receptions.
7. Reggie Nelson, DB (2007 - 21st Overall)
It's rumored the Jaguars coveted Darrelle Revis in the draft. When he was selected by the New York Jets, the Jags settled for Nelson. He followed up a promising rookie season with a couple of unspectacular seasons, and was eventually traded to the Cincinnati Bengals.
8. Derrick Harvey, DE (2008 - 8th Overall)
Derrick Harvey was the last draft pick by Jaguars former GM Shack Harris. Harvey was expected to be the Jaguars best pass rusher, but he never panned out. He only recorded 8 sacks over three seasons before being cut.
9. Eugene Monroe, LT (2009 - 8th Overall)
Eugene Monroe was drafted to be the Jaguars bookend left tackle (the blind-side protector). He was Jaguars' GM Gene Smith's first selection. Monroe hasn't developed into a Pro-Bowl caliber player, but he has become a solid starter.
10. Tyson Alualu, DT (2010 - 10th Overall)
The jury is still out on Tyson Alualu -- the former Hawaii star has battled injuries for most of his young career.
11. Blaine Gabbert, QB (2011 - 10th Overall)
With Gabbert, the Jaguars selected only their second quarterback in the first round in club history. His rookie season is widely considered a disappointment, and injuries have set him back in his sophomore campaign. As of November 2012, it's unclear if Gabbert will retain his starting position in 2013.
12. Justin Blackmon, WR (2012 - 5th Overall)
Blackmon started his 2012 rookie season slow, but exploded against the Houston Texans in Week 10 for more than 200 receiving yards. He's a talented and physical wide receiver who looks like a keeper for the long term.